DRUGS AND THEIR ACTIVE METABOLITES
SR.NO. DRUG ACTIVE METABOLITE
1 Allopurinol Oxipurinol (Alloxanthine)
2 Amytryptylline Nortryptalline
3 Amphetamine P-Methoxy Amphetamine
4 Carmapazepine Carmapazemine-10,11-Eporide
5 Carbimazole Thiamazole
6 Cephaloglycine Desacetyl Cephaloglycine
7 Chloral Hydrate Trichloroethanol
8 Chlordiazepoxide 7-hydroxy Chloropromazine
9 Chlorpromazine 7-hydroxy Chloropromazine
10 Chlorguanidine Cyclogunal
11 Clofibrate Free acid metabolite
12 Imipramine N-oxide metabolite
13 Codeine Morphine,Norcodeine
14 Diazepam Oxazepam.N-Me-Oxazepam
15 Fenfluramine Nor Fenfluramine
16 Guanethadine N-Oxide
17 Lignocaine N-Desmethyl metabolite
18 Morphine Nor morphine
19 Naloxane 6-ô€€€-hydroxy Naloxane
20 Phenacetin Paracetamol
21 Prednisone Prednisolone
22 Premidone Phenobarbitone
23 Spironolactone Canrenone
24 Procainamide N-Acetyl metabolite
25 Propanolol N-deisopropyl met
26 Quinidine 3-Hydroxy quinone
27 Rifampicine Desacetylated metabolite
28 Thioridazine Mesoridazine
29 Trimethedione Dimethedione
30 Warfarin Warfarin alcohol
31 Vit D 1,2 Dihydroxy metabolite
32 Reserpine Methyl reserpate
PRODUCTS AND ANIMALS USED FOR BIOASSAYS
SR DRUG PRODUCT ANIMAL
1 Digitalis Pigeon
2 Glycogen Cat
3 Insulin inj, Rabbit
4 Oxytocin Chicken
5 Parathyroid Dog
6 Vasopressin Rat
7 Posterior pituitary Chicken
8 Tubocurarine chloride Rabbit
9 Chorionic gonadotropin Male rat
10 Cod liver oil Rachitic rat
11 Heparin sodium Sheep
12 Iron dextran injection Microbial cultures
13 Antiseptic and disinfectant Frog
14 Fungicides and Herbicides Mouse
15 Diphtheria toxoid Rat
16 Atropine Rabbit
17 Insulin inj. Guinea pig
18 Elastomeric closures Plastic containers Guinea pig
RECOMENDE NEEDLE SIZE FOR VARIOUS INJECTIONS
INJECTIONS GUAGE LENGTH IN INCHES
INTRADERMAL 26G ¼ or 3/8
S.C 26G ½-¾
25G ½-¾
22G 1 ½
I.M 24G ¾-1
23G 1
22G 1
20G 1 ½
I.V 22G 1-1/4-1 ½
20G 1 ½
DRUGS AND THEIR VARIETIES
DRUG VARIETY
1 SENNA
Indian senna Cassia angustifolia
Alexandrian senna Cassia acutifolia
Dog senna Cassia obovata
Palthe senna Cassia auriculata
2 ALOE
Cape Aloe Aloe ferox
Curcao Aloe Aloe barbadensis
Socotriene/ Zangibar aloe Aloe perryii
3 RHUBARB
Indian Rhubarb Rheum emodi
Chienese Rhubarb Rheum Webbianum
DRUG AND THEIR SYNONYMS
SR.NO. DRUG SYNONYMS
1 Cinchona Panama bark
2 Lanolin Wool fat
3 Crowfig seeds Nuxvomica
4 Deadly night shade Atropa beladona
5 Digitalis purpuria Foxglove
6 American podophyllum May apple
7 Indian tragacanth Gum karaya
8 Devil’s dung Asafoetida
9 Indian squill Urgenia
10 Indian tobacco Lobelia
11 Flax seeds Linseed
12 Periwinkle Vinca visea
13 Ashwagandha Withania somnifera
14 Alexendrian senna Cassia acutifolia
15 Tinevally senna Cassia angustifolia
16 Dog senna Cassia obovata
17 Pathe senna Cassia auriculata
18 Acasia Gum arabica
19 Sterculia Karaya
20 Agar Japnese is linglass
21 Plantago Psyllium
22 Starch Amylum
23 Rhubarb Rheam.emodi.(IND.Rhubarb)
24 Cascara Purshiana,sacred barc
25 Discoria Wild Yam
26 Glycerrhiza Liquarice
27 Quillalia Panama bark
28 Quassia Bitter wool
29 Pale calicher Gambier catechu
30 Blach caticher Cutch
31 Castor oil Ricinus oil
32 Arachis oil Reauut oil
33 Linseed iol Flax seed oil
34 Olive oil Saled oil
35 Hydro carpno oil Chanlmogra oil
36 Theobrona oil Cocoa butter
37 Cinnamon Chinese cassia
38 Saffron Crocus
39 Colchicum Autumn Crocus, Meadow saffron seeds
40 Nutmeg Mygistica
41 Chenopodium American wore
42 Lipstick tree Annato tree, Bixin
43. Clove Caryo phylum
NAME OF THE DRUG AND SIDE EFFECTS
SR NO NAME OF THE DRUG SIDE EFFECTS
1 ACE Inhibitors Dry Cough
2 Amphotericin-B Nephrotoxicity
3 Ampicillin Hypersensitivity
4 Androgen Virilization
5 Antipsychotics Sedation, Orthostatic hypotension, Tardive dyskinesia
6 Anti- TB Hepatotoxicity
7 Aspirin (cox-I Inhibitors) Hepatotoxicity
8 Atropine Dryness of mouth, Blurred vision, Constipation
9 Celecoxib, Valdecoxib (cox-II Inhibitors), Hepatotoxicity
10 Chlorambucil Alopecia
11 Chloramphenicol Grey baby syndrome, Bone marrow depression
12 Chloroquine Phototoxicity
13 Ciprofloxacin Phototoxicity
14 Clofazimine Pigmentation of skin, Discoloration of Urine
15 Clozapine Agranulocytosis
16 Erythromyicin Cholestatic Juandice
17 Ethambutol Optic Neuritis, Retrobulbular Neuritis
18 Hydrochlorthiazide Hypokalamia
19 Isoniazid Peripheral Neurtis
20 Metronidazole Disulfiram like reaction
21 Minoxidil Hirsutism
22 Morphine Constipation
23 Nimesulide Hepatotoxicity
24 Nitrogen Mustard Bone marrow depression
25 Nitroglycerin Palpitation
26 Penicillin-G Jarisch Heximer Reaction
27 Phenformin Lactic acidosis, GI disturbance, Metalic taste
28 Phenytoin Hirsutism
29 Quinidine Cinchonism
30 Quinine Sulphate Black Water Fever
31 Repaglinide Althralgia
32 Rosaglitazone Anemia,Weight gain
33 Sitagliptin Coldness
34 Spironolactone Hyperkalamia
35 Cimetidine Gynacomastia
37 Sulfonyl Ureas derivatives Bone marrow depression
38 Terfenadine Type-I arrhythmia
39 Tetracyclines Discoloration of teeth
40 Thalidomide Phocomelia
CAPSULE NO & THEIR APPROXIMATE CAPACITY IN mg & ml
CAPSULE SIZE Mg Ml
000 (Largest) 950 1.37
00 650 0.95
0 450 0.68
1 300 0.50
2 250 0.37
3 200 0.30
4 150 0.21
5 (Smallest) 100 0.13
PROPORTIONS REQUIRED FOR A PRIMARY EMULSION
TYPE OF OIL OIL: WATER: GUM RATIO
FIXED OILS 4:2:1
VOLATILE OILS 2:2:1
MINERAL OILS 3:2:1
OLEORESINS 1:2:1
CODE:
SR.NO. DRUG ACTIVE METABOLITE
1 Allopurinol Oxipurinol (Alloxanthine)
2 Amytryptylline Nortryptalline
3 Amphetamine P-Methoxy Amphetamine
4 Carmapazepine Carmapazemine-10,11-Eporide
5 Carbimazole Thiamazole
6 Cephaloglycine Desacetyl Cephaloglycine
7 Chloral Hydrate Trichloroethanol
8 Chlordiazepoxide 7-hydroxy Chloropromazine
9 Chlorpromazine 7-hydroxy Chloropromazine
10 Chlorguanidine Cyclogunal
11 Clofibrate Free acid metabolite
12 Imipramine N-oxide metabolite
13 Codeine Morphine,Norcodeine
14 Diazepam Oxazepam.N-Me-Oxazepam
15 Fenfluramine Nor Fenfluramine
16 Guanethadine N-Oxide
17 Lignocaine N-Desmethyl metabolite
18 Morphine Nor morphine
19 Naloxane 6-ô€€€-hydroxy Naloxane
20 Phenacetin Paracetamol
21 Prednisone Prednisolone
22 Premidone Phenobarbitone
23 Spironolactone Canrenone
24 Procainamide N-Acetyl metabolite
25 Propanolol N-deisopropyl met
26 Quinidine 3-Hydroxy quinone
27 Rifampicine Desacetylated metabolite
28 Thioridazine Mesoridazine
29 Trimethedione Dimethedione
30 Warfarin Warfarin alcohol
31 Vit D 1,2 Dihydroxy metabolite
32 Reserpine Methyl reserpate
PRODUCTS AND ANIMALS USED FOR BIOASSAYS
SR DRUG PRODUCT ANIMAL
1 Digitalis Pigeon
2 Glycogen Cat
3 Insulin inj, Rabbit
4 Oxytocin Chicken
5 Parathyroid Dog
6 Vasopressin Rat
7 Posterior pituitary Chicken
8 Tubocurarine chloride Rabbit
9 Chorionic gonadotropin Male rat
10 Cod liver oil Rachitic rat
11 Heparin sodium Sheep
12 Iron dextran injection Microbial cultures
13 Antiseptic and disinfectant Frog
14 Fungicides and Herbicides Mouse
15 Diphtheria toxoid Rat
16 Atropine Rabbit
17 Insulin inj. Guinea pig
18 Elastomeric closures Plastic containers Guinea pig
RECOMENDE NEEDLE SIZE FOR VARIOUS INJECTIONS
INJECTIONS GUAGE LENGTH IN INCHES
INTRADERMAL 26G ¼ or 3/8
S.C 26G ½-¾
25G ½-¾
22G 1 ½
I.M 24G ¾-1
23G 1
22G 1
20G 1 ½
I.V 22G 1-1/4-1 ½
20G 1 ½
DRUGS AND THEIR VARIETIES
DRUG VARIETY
1 SENNA
Indian senna Cassia angustifolia
Alexandrian senna Cassia acutifolia
Dog senna Cassia obovata
Palthe senna Cassia auriculata
2 ALOE
Cape Aloe Aloe ferox
Curcao Aloe Aloe barbadensis
Socotriene/ Zangibar aloe Aloe perryii
3 RHUBARB
Indian Rhubarb Rheum emodi
Chienese Rhubarb Rheum Webbianum
DRUG AND THEIR SYNONYMS
SR.NO. DRUG SYNONYMS
1 Cinchona Panama bark
2 Lanolin Wool fat
3 Crowfig seeds Nuxvomica
4 Deadly night shade Atropa beladona
5 Digitalis purpuria Foxglove
6 American podophyllum May apple
7 Indian tragacanth Gum karaya
8 Devil’s dung Asafoetida
9 Indian squill Urgenia
10 Indian tobacco Lobelia
11 Flax seeds Linseed
12 Periwinkle Vinca visea
13 Ashwagandha Withania somnifera
14 Alexendrian senna Cassia acutifolia
15 Tinevally senna Cassia angustifolia
16 Dog senna Cassia obovata
17 Pathe senna Cassia auriculata
18 Acasia Gum arabica
19 Sterculia Karaya
20 Agar Japnese is linglass
21 Plantago Psyllium
22 Starch Amylum
23 Rhubarb Rheam.emodi.(IND.Rhubarb)
24 Cascara Purshiana,sacred barc
25 Discoria Wild Yam
26 Glycerrhiza Liquarice
27 Quillalia Panama bark
28 Quassia Bitter wool
29 Pale calicher Gambier catechu
30 Blach caticher Cutch
31 Castor oil Ricinus oil
32 Arachis oil Reauut oil
33 Linseed iol Flax seed oil
34 Olive oil Saled oil
35 Hydro carpno oil Chanlmogra oil
36 Theobrona oil Cocoa butter
37 Cinnamon Chinese cassia
38 Saffron Crocus
39 Colchicum Autumn Crocus, Meadow saffron seeds
40 Nutmeg Mygistica
41 Chenopodium American wore
42 Lipstick tree Annato tree, Bixin
43. Clove Caryo phylum
NAME OF THE DRUG AND SIDE EFFECTS
SR NO NAME OF THE DRUG SIDE EFFECTS
1 ACE Inhibitors Dry Cough
2 Amphotericin-B Nephrotoxicity
3 Ampicillin Hypersensitivity
4 Androgen Virilization
5 Antipsychotics Sedation, Orthostatic hypotension, Tardive dyskinesia
6 Anti- TB Hepatotoxicity
7 Aspirin (cox-I Inhibitors) Hepatotoxicity
8 Atropine Dryness of mouth, Blurred vision, Constipation
9 Celecoxib, Valdecoxib (cox-II Inhibitors), Hepatotoxicity
10 Chlorambucil Alopecia
11 Chloramphenicol Grey baby syndrome, Bone marrow depression
12 Chloroquine Phototoxicity
13 Ciprofloxacin Phototoxicity
14 Clofazimine Pigmentation of skin, Discoloration of Urine
15 Clozapine Agranulocytosis
16 Erythromyicin Cholestatic Juandice
17 Ethambutol Optic Neuritis, Retrobulbular Neuritis
18 Hydrochlorthiazide Hypokalamia
19 Isoniazid Peripheral Neurtis
20 Metronidazole Disulfiram like reaction
21 Minoxidil Hirsutism
22 Morphine Constipation
23 Nimesulide Hepatotoxicity
24 Nitrogen Mustard Bone marrow depression
25 Nitroglycerin Palpitation
26 Penicillin-G Jarisch Heximer Reaction
27 Phenformin Lactic acidosis, GI disturbance, Metalic taste
28 Phenytoin Hirsutism
29 Quinidine Cinchonism
30 Quinine Sulphate Black Water Fever
31 Repaglinide Althralgia
32 Rosaglitazone Anemia,Weight gain
33 Sitagliptin Coldness
34 Spironolactone Hyperkalamia
35 Cimetidine Gynacomastia
37 Sulfonyl Ureas derivatives Bone marrow depression
38 Terfenadine Type-I arrhythmia
39 Tetracyclines Discoloration of teeth
40 Thalidomide Phocomelia
CAPSULE NO & THEIR APPROXIMATE CAPACITY IN mg & ml
CAPSULE SIZE Mg Ml
000 (Largest) 950 1.37
00 650 0.95
0 450 0.68
1 300 0.50
2 250 0.37
3 200 0.30
4 150 0.21
5 (Smallest) 100 0.13
PROPORTIONS REQUIRED FOR A PRIMARY EMULSION
TYPE OF OIL OIL: WATER: GUM RATIO
FIXED OILS 4:2:1
VOLATILE OILS 2:2:1
MINERAL OILS 3:2:1
OLEORESINS 1:2:1
CODE:
OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. OSI-420
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