MECHANISMS OF DRUG ACTION A. Interaction with receptors 1. Agonists interact with specific cellular constituents, known as receptors, and elicit an observable biological response. Agonists have both affinity for the receptor and intrinsic activity. 2. Partial agonists interact with the same receptors as full agonists but are unable to elicit the same maximum response. Partial agonists have lower intrinsic activity than full agonists; however, their affinity for the receptor can be greater than, less than, or equal to that of full agonists. 3. Antagonists inhibit the actions of agonists. a. Pharmacological antagonists bind to the same receptor as the agonist, either at the same site or at an allosteric site. They have affinity for the receptor but lack intrinsic activity. Pharmacological antagonists can be subdivided into reversible, irreversible, competitive, and noncompetitive categories similar to enzym
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